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NCI - National Cancer Institute
06/08/2012 | Press release
Mount Sinai and UCSF researchers develop a multi-target approach to treating tumors
distributed by noodls on 06/09/2012 20:21
NCI Cancer Center News
Mount Sinai and UCSF researchers develop a multi-target approach to treating tumors
Researchers from Mount Sinai School of Medicine and collaborators from the University of California, San Francisco developed a cancer model built in the fruit fly Drosophila, then used it to create a whole new approach to the discovery of cancer treatments. The result is an investigational compound AD80 that precisely targets multiple cancer genes. Tested in mouse models, the drug proved far more effective and less toxic than standard cancer drugs, which generally focus on a single target. This is the first time that whole-animal screening has been used in a rational, step-wise approach to polypharmacology. The study appears online in the journal Nature.
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Among the research institutions NCI funds across the United States, it currently designates 66 as Cancer Centers. Largely based in research universities, these facilities are home to many of the NCI-supported scientists who conduct a wide range of intense, laboratory research into cancer's origins and development. The Cancer Centers Program also focuses on trans-disciplinary research, including population science and clinical research. The centers' research results are often at the forefront of studies in the cancer field.
